Macrocephaly in neurofibromatosis type 1: a sign post for optic pathway gliomas?
نویسندگان
چکیده
منابع مشابه
Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.
Neurofibromatosis type 1 is a common neurogenetic disorder characterized by significant clinical variability. As such, numerous studies have focused on identifying clinical, radiographic, or molecular biomarkers that predict the occurrence or progression of specific clinical features in individuals with neurofibromatosis type 1. One of these clinical biomarkers, macrocephaly, has been proposed ...
متن کاملNeurofibromatosis type 1 and sporadic optic gliomas.
AIMS To compare the natural history of sporadic optic glioma with those associated with neurofibromatosis type 1 (NF1). METHODS Optic glioma cases were identified using both the Manchester Children's Tumour Registry (CTR) and the North West Regional NF1 Database (NF1DB), with detailed information on natural history available from the former (in 34 of 36 cases identified). RESULTS A total of...
متن کاملMRI Screening for Optic Gliomas in Neurofibromatosis Type 1.
Investigators from Cincinnati Children's Hospital, OH, analysed retrospectively the utility of screening brain/orbital MRIs in 826 children with NF1 (ages 1-9 years; 402 female, 424 male) seen over a 20-year period between 1990 and 2010.
متن کاملFractional anisotropy of the optic radiations is associated with visual acuity loss in optic pathway gliomas of neurofibromatosis type 1.
BACKGROUND No more than half of patients with neurofibromatosis type 1 (NF1)-associated optic pathway gliomas (OPGs) develop vision loss. Prospectively identifying those who will require therapy remains challenging, because no reliable factors have yet been identified that predict future vision loss. To determine whether brain tissue microstructure is associated with visual acuity loss, we exam...
متن کامل2441 Optic pathway gliomas in neurofibromatosis and non-neurofibromatosis patients: A comparative study
Purpose: Visual symptom6 and siSm & with Central NSystem (CNS) tumours rm frequent Se, ~~~~-@thahtte~d tixamidm d treatment of theBe tutualrs. The aldhas mede&tians in 61 children pkntiag CNS tumatm. Clinical, hyn@&dcgitxd andanatmnical cotnlations arepreadedinddiecuned. lteeultr: Differat hyraqmblo&al m of CNS hlmow werefald astmcylomas (46.1 %) arsbellum Mmytormv (5.0 %)), tuaim Yaocyuanss (9...
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ژورنال
عنوان ژورنال: Child's Nervous System
سال: 2011
ISSN: 0256-7040,1433-0350
DOI: 10.1007/s00381-011-1554-2